CATEGORY :
Antiacne , Antibacterial .
MECHANISM OF ACTIONS :
Clindamycin Suppresses bacterial protein
synthesis .Topical Clindamycin is thought to
reduce free fatty acid concentrations on the
skin and to suppress the growth of
propionibacterium acnes , corynebacterium acnes
, and anaerobe found in sebaceous glands and
follicles .
P . acnes produces proteases , hyaluronidases ,
lipases , and chemotactic factors , all of which
can produce inflammatory components or
inflammation directly .
PHARMACOKINETICS :
Approximately 1.7% absorbed through the skin
following topical application .
Elimination :
Renal , 0.15% to 0.25% of cumulative dose
excreted in urine following topical application
of the solution every 12 hours .
INDICATIONS :
Topical Clindamycin is indicated in treatment of
acne vulgaris and it is used in the topical
treatment of erythrasma caused by
corynebacterium , minutissimum rosacea .
periorificial facial dermatitis , folliculitis ,
stasis , chronic lymphedema , and familial
pemphigus .
Topical Clindamycin is not effective in the
treatment of deep cystic lesions or non
inflammatory lesions .
DRUG INTERACTIONS :
Abrasive or medicated soap or cleansers or Acne
preparations or preparations containing a
peeling agent .
Alcohol-containing preparations
topical . cosmetics or soaps with a strong
drying effect or Isoteretinoin or medicated
cosmetics or coverups .
ADVERSE EFFECTS :
Contact dermatitis or hypersensitivity ,
pseudomembraneous colitis , dryness , scaliness
or peeling of skin , gastrointestinal
disturbances , stinging or burning feeling of
skin , sensitization or oilness of skin . |
