CATEGORY :
Antifungal .
MECHANISM OF ACTIONS :
Fungistatic , may be fungicidal , depending on
concentration , exact mechanism of action is
unknown . Azoles inhibit biosynthesis of
ergosterol or other sterols , damaging the
fungal cell membrane .
Azoles also inhibit biosynthesis of
triglycerides and phospholipids by fungi . In
addition , Azoles inhibit oxidative and
peroxidative enzyme activity .
PHARMACOKINETICS :
Small amounts absorbed systemically following
intravaginal administration and topical
administration .
INDICATIONS :
Vulvovaginal candidiasis . Not all species or
strains of a particular organism may be
susceptible to a specific vaginal azole .
Vaginal azoles are not effective in the
treatment of vulvovaginitis caused by other
common pathogens such as trichomonas vaginalis .
ADVERSE EFFECTS :
Occasional local irritation and hypersensitivity
reaction include mild burning sensation ,
erythema and itching , headache , hives and skin
rash may occur . Treatment should be
discontinued if these are severe .
Incidence less frequent or rare : Abdominal or
stomach cramps or pain , burning or irritation
of penis of sexual partner . |
