CATEGORY :
Antifungal .
MECHANISM OF ACTIONS :
Azoles inhibit biosynthesis of ergosterol or
other sterols , damaging the fungal cell
membrane .
Azoles also inhibit biosynthesis of
triglycerides and phospholipids by fungi . In
addition , Azoles inhibit oxidative and
peroxidative enzyme activity .Miconazole
interferes with mitochondrial and peroxisomal
enzymes , resulting in intracellular necrosis .
It inhibits growth of the common dermatophytes ,
Trichophyton rubrum , T. mentagrophytes ,
Epidermophyton floccosum , Candida Albicans and
the active organism in Tinea versicolor ,
Malassezia furfur .
PHARMACOKINETICS :
Miconazole alters cellular membrane permeability
and interferes with mitochondrial and
peroxisomal enzymes , resulting in intracellular
necrotics .
INDICATIONS :
Prescriptional and OTC :
Tinea pedis ( athletes` foot ) , Tinea cruris (
jock itch ) and Tinea corporis ( ring worm )
caused by T.ruberum , T. mentagrophytes and
E.floccosum .
Prescriptional only :
Cutaneous candidiasis ( moniliasis ) , Tinea
versicolor .
ADVERSE EFFECTS :
Irritation , burning , maceration and allergic
contact dermatitis . |
