|
|
 |
CATEGORY :
Anti-pigmentation
MECHANISM OF ACTIONS :
Monobenzone is a depigmenting agent whose
mechanism of its action is not fully understood
.The topical application of Monobenzone in
animals , increases the excretion from the
melanocytes .
The same action is thought to be
responsible for the depigmenting effect of the
drug in humans . Monobenzone may cause
destruction of melanocytes and permanent
depigmentation .
This effect is erratic and may
take one to four months to occur , while
existing melanin is lost with normal sloughing
of the stratum corneum .
INDICATIONS :
Monobenzone topical cream is indicated for final
depigmentation in excessive vitiligo .
Monobenzone cream is applied topically to
permanently depigment normal skin surrounding
vitiliginous lesions in patients with
disseminated
( greater than 50% of body surface
area ) idiopatic vitiligo .
CONTRAINDICATIONS :
Freckling , hyperpigmentation due to
photosensitization following use of certain
perfumes or following inflammation of the skin ,
melasma , chloasma of pregnancy , cafe – au –
lait spots , pigmented nevi , malignant melanoma
, pigment resulting from pigments other than
melanin , including bile , silver and artificial
pigments , hypersensitivity to Monobenzone or
any ingredients of the product .
PRECAUTIONS :
• Hyperpigmented
skin appears to fade more rapidly than those
normal skin , and exposure to sun reduces the
depigmenting effect of the drug .
• Following therapy
with Monobenzone cream , the skin will be
sensitive for the rest of the patients life and
sunscreen should be used during exposure to
sunlight .
ADVERSE EFFECTS :
Irritation , burning , sensation , dermatitis . |
W A
R N I
N G S
:
• For external use only. Avoid contact with the
eyes .
• Monobenzone frequently causes irreversible
depigmentation , it must not be used as a
substitute for hydroquinone .
• Monobenzone is a potent depigmentating agent ,
not a mild cosmetic skin bleach .
• Do not use except for final depigmentation in
disseminated vitiligo .
• Usage in pregnancy :
category C
• Usage in lactation :
use with caution in nursing mother .
• Usage in children :
safety and efficacy in children < 12 years of
age have not been established . |
DOSAGE :
Apply and rub into the pigmented areas to be
treated , 2 or 3 times daily . Depigmentation is
usually observed after 1 to 4 months of therapy.
If satisfactory results have not been obtained
within 4 months , discontinue treatment .
HOW SUPPLIED :
Topical cream 20% in 30 gram tubes .
STORAGE :
Monobenzone cream should be Store below 30º C and preserved from freezing . |
|
ACETAMINOPHEN SUPPOSITORY 125 mg & 325 mg
ACICLOVIR TOPICAL CREAM 5%
ANTIHEMORRHOID RECTAL OINTMENT & SUPPOSITORY
BENZYDAMINE ORAL
SOLUTION 0.15%
BURN OINTMENT
CALAMINE LOTION 8%
CETYLPYRIDINIUM CHLORIDE MOUTHWASH 0.05%
CLINDAMYCIN PHOSPHATE TOPICAL GEL 1%
CLINDAMYCIN PHOSPHATE VAGINAL CREAM 2%
CLOBETASOL PROPIONATE TOPICAL CREAM 0.05%
CLOTRIMAZOLE TOPICAL SOLUTION & CREAM 1%
CLOTRIMAZOLE VAGINAL CREAM 1%
HAEMODIALYSIS SOLUTION
HYDROQUINONE TOPICAL CREAM 4%
KETOCONAZOLE TOPICAL CREAM 2%
KETOCONAZOLE SHAMPOO 2%
LINDANE LOTION 1%
MICONAZOLE NITRATE TOPICAL CREAM 2%
MICONAZOLE NITRATE VAGINAL CREAM 2%
MONOBENZONE TOPICAL CREAM 20%
NAPROXEN SUPPOSITORY 500 mg
NITROFURAZONE TOPICAL CREAM 0.2%
PIROXICAM SUPPOSITORY 20 mg
POVIDONE IODINE VAGINAL GEL 10%
POVIDONE IODINE SURGICAL SCRUB 7.5%
POVIDONE IODINE SOLUTION 10%
POVIDONE IODINE VAGINAL DOUCHE 10%
POVIDONE IODINE SHAMPOO 7.5%
SODIUM FLOURIDE MOUTHWASH 0.2%
TERBINAFINE HCL TOPICAL CREAM 1%
TRIPLE SULFA VAGINAL CREAM
VITAMIN A+D OINTMENT |
