CATEGORY :
Nonsteroidal Anti-inflammatory
MECHANISM OF ACTIONS :
NSAIDs in addition to anti-inflammatory effects
have analgesic and antipyretic activities .
Major mechanism is believed to be inhibition of
cycloxygenase activity and prostaglandin
synthesis .
PHARMACOKINETICS :
Piroxicam is well absorbed from the gastro –
intestinal tract . Piroxicam is 99% bound to
plasma proteins . Less than 5% of the dose is
excreted unchanged in the urine .
INDICATIONS :
Indicated for Rheumatoid Arthritis ( RA ) ,
Osteoarthritis , Ankylosing spondylitis , acute
attacks of gout or calcium pyrophosphate
deposition disease ( pseudogout ) , and
dysmenorrhea .
CONTRAINDICATIONS :
Due to possibility of cross – sensitivity ,
Piroxicam suppositories should not be given to
patients with hypersensitivity to Aspirin ,
iodide and other NSAIDs .
DRUG INTERACTIONS :
Drugs that affect NSAIDS include Cimetidine ,
Probenecid , Salicylates , and DMSO . Drugs that
are affected by NSAIDs include anticoagulants ,
ACEIs , Betablockers , Cyclosporine ,
Dipyridamole , lithium , loop diuretics ,
Methotrexate , Penicillamine , Sympathomimetics
, and Thiazide diuretics . Concurrent
administration of aspirin results in decreased
plasma concentrations of Piroxicam to about 80%
of normal . Concomitant administration of
Piroxicam and Ritonavir may result in increased
plasma concentrations of Piroxicam and carries
increased risk of toxicity , use together should
be avoided .
ADVERSE EFFECTS :
As for NSAIDS in general , Local irritation and
occasionally bleeding may occur with Piroxicam
suppositories . |
