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CATEGORY :
Dental caries prophylactic , nutritional
supplement .
MECHANISM OF ACTIONS :
Fluoride ion becomes incorporated into and
stabilizes the apatite crystal of bone and teeth
. Fluoride acts primarily to promote
remineralization of decalcified enamel and may
interfere with growth and development of dental
plaque bacteria . Deposition of fluoride ion in
the enamel surface of teeth increases resistance
to acid and to development of caries .
PHARMACOKINETICS :
Fluorides in solution or in the form of rapidly
soluble salts are rapidly and almost completely
absorbed from the gastrointestinal tract .
INDICATIONS :
Dental caries prophylaxis .
DRUG INTERACTIONS :
Aluminium , calcium and magnesium salt may
decrease the absorption of fluoride . |
W A
R N I
N G S
:
• Avoid use for
children aged under 6 years because they are
unable to effectively spit the rinse out after
use .
• Care should be
taken to prevent children swallowing excessive
fluoride after topical application .
• Fluoride solution
should not be used with glass since fluoride
etches glass . Therefore solution should be
directly dropped into the mouth .
• Excessive doses
of fluoride may result in fluorosis of teeth if
taken during tooth formation years .
•
Usage in
pregnancy and lactation : Problems in humans
have not been documented with normal recommended
dose . |
ADVERSE EFFECTS :
Recommended doses have not been shown to have
significant side effects ; only occasional white
flecks on teeth with recommended doses , rarely
yellowish – brown discoloration if recommended
doses are exceeded .
DOSAGE :
Sodium fluoride solution should be used
topically as a rinse and mouthwash .
Rinse mouth for one minute and spit out . For
maximum benefit eating , drinking or rinsing
should be avoided for at least 15-30 min after
fluoride solution application .
OVER DOSAGE :
In case of accidental ingestion and acute
poisoning , treatment includes :
Gastric lavage with lime water or a weak
solution of another calcium salt to precipitate
fluoride maintenance of high urine output , slow
intravenous injections of calcium gluconate 10%
for hypocalcemia ,tetany ,symptomatic and
systemic measures. Haemodialysis may be
considered .
HOW SUPPLIED :
Mouthwash 0.2% in 250 mL bottles .
STORAGE :
Keep the medicine from freezing and in tight
plastic container .
Store below 30º C
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ACETAMINOPHEN SUPPOSITORY 125 mg & 325 mg
ACICLOVIR TOPICAL CREAM 5%
ANTIHEMORRHOID RECTAL OINTMENT & SUPPOSITORY
BENZYDAMINE ORAL
SOLUTION 0.15%
BURN OINTMENT
CALAMINE LOTION 8%
CETYLPYRIDINIUM CHLORIDE MOUTHWASH 0.05%
CLINDAMYCIN PHOSPHATE TOPICAL GEL 1%
CLINDAMYCIN PHOSPHATE VAGINAL CREAM 2%
CLOBETASOL PROPIONATE TOPICAL CREAM 0.05%
CLOTRIMAZOLE TOPICAL SOLUTION & CREAM 1%
CLOTRIMAZOLE VAGINAL CREAM 1%
HAEMODIALYSIS SOLUTION
HYDROQUINONE TOPICAL CREAM 4%
KETOCONAZOLE TOPICAL CREAM 2%
KETOCONAZOLE SHAMPOO 2%
LINDANE LOTION 1%
MICONAZOLE NITRATE TOPICAL CREAM 2%
MICONAZOLE NITRATE VAGINAL CREAM 2%
MONOBENZONE TOPICAL CREAM 20%
NAPROXEN SUPPOSITORY 500 mg
NITROFURAZONE TOPICAL CREAM 0.2%
PIROXICAM SUPPOSITORY 20 mg
POVIDONE IODINE VAGINAL GEL 10%
POVIDONE IODINE SURGICAL SCRUB 7.5%
POVIDONE IODINE SOLUTION 10%
POVIDONE IODINE VAGINAL DOUCHE 10%
POVIDONE IODINE SHAMPOO 7.5%
SODIUM FLOURIDE MOUTHWASH 0.2%
TERBINAFINE HCL TOPICAL CREAM 1%
TRIPLE SULFA VAGINAL CREAM
VITAMIN A+D OINTMENT |
