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CATEGORY :
Anti-infective (Sulfonamide) . Triple Sulfa
vaginal cream contains 3 active ingredients with
bacteriostatic action, namely sulfathiazole,
sulfabenzamide and sulfacetamide.
MECHANISM OF ACTIONS :
Susceptible microorganisms require extracellular
PABA in order to form dihydrofolic Acid , an
essential step in the production of purines and
the synthesis of nuclic acids . Sulfonamides are
dihydropteroate synthetase .
They inhibit growth
by reversibly blocking folic acid synthesis .
Accordingly , sulfonamides are bacteriostatic
drugs , not bactericidal . Sulfonamides inhibit
both G+ and G- bacteria , Nocardia , Chlamydia
trachomatis , and some protozoa .
PHARMACOKINETICS :
Sulfonamides are absorbed through the vaginal
mucosa .
INDICATIONS :
Triple sulfa is indicated for treatment of
Haemophilus vaginalis vaginitis and Gardnerella
vaginalis vaginitis .
CONTRAINDICATIONS :
Hypersensitivity to any component and kidney
disease .
ADVERSE EFFECTS :
Local irritations and rarely allergic reactions,
pruritus, urticaria and vulvitis. |
W A
R N I
N G S
:
• Patients
hypersensitive to one sulfonamide may be
hypersensitive to other sulfonamides also.
• Patient
hypersensitive to Furosemide, Sulfones, Thiazide-diuretics,
Sulfonylureas, or carbonic anhydrase inhibitors
may be hypersensitive to sulfonamides also.
• If local
irritation develops or systemic toxicity is
evident , discontinue the treatment.
•
Usage in
pregnancy : category C
•
Usage in
lactation : sulfonamides appear in maternal milk
and have caused kernicterus in the newborn .
sulfonamides may cause hyperbilirubinemia in the
infant . In addition sulfonamides may cause
hemolytic Anemia in G6PD deficient neonates .
Because of the potential for serious adverse
reactions in the nursing infant , decide whether
to discontinue nursing or discontinue the drug ,
taking into account the importance of the drug
to the mother .
• If local
irritations develop or if systemic toxicity is
evident , discontinue treatment . |
DOSAGE :
Cream Intravaginal , 1 applicatorful (5g) two
times a day for 4-6 days then the dose may be
reduced to ½ to ¼ applicatorful 2 times a day.
HOW SUPPLIED :
Sulfathiazole 3.42 %, sulfacetamide 2.86%,
sulfabenzamide 3.70% in tubes of 78g, with
applicator .
STORAGE :
Store below 30º C
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ACETAMINOPHEN SUPPOSITORY 125 mg & 325 mg
ACICLOVIR TOPICAL CREAM 5%
ANTIHEMORRHOID RECTAL OINTMENT & SUPPOSITORY
BENZYDAMINE ORAL
SOLUTION 0.15%
BURN OINTMENT
CALAMINE LOTION 8%
CETYLPYRIDINIUM CHLORIDE MOUTHWASH 0.05%
CLINDAMYCIN PHOSPHATE TOPICAL GEL 1%
CLINDAMYCIN PHOSPHATE VAGINAL CREAM 2%
CLOBETASOL PROPIONATE TOPICAL CREAM 0.05%
CLOTRIMAZOLE TOPICAL SOLUTION & CREAM 1%
CLOTRIMAZOLE VAGINAL CREAM 1%
HAEMODIALYSIS SOLUTION
HYDROQUINONE TOPICAL CREAM 4%
KETOCONAZOLE TOPICAL CREAM 2%
KETOCONAZOLE SHAMPOO 2%
LINDANE LOTION 1%
MICONAZOLE NITRATE TOPICAL CREAM 2%
MICONAZOLE NITRATE VAGINAL CREAM 2%
MONOBENZONE TOPICAL CREAM 20%
NAPROXEN SUPPOSITORY 500 mg
NITROFURAZONE TOPICAL CREAM 0.2%
PIROXICAM SUPPOSITORY 20 mg
POVIDONE IODINE VAGINAL GEL 10%
POVIDONE IODINE SURGICAL SCRUB 7.5%
POVIDONE IODINE SOLUTION 10%
POVIDONE IODINE VAGINAL DOUCHE 10%
POVIDONE IODINE SHAMPOO 7.5%
SODIUM FLOURIDE MOUTHWASH 0.2%
TERBINAFINE HCL TOPICAL CREAM 1%
TRIPLE SULFA VAGINAL CREAM
VITAMIN A+D OINTMENT |
